A meta-analysis of efficacy and safety of doripenem for treating bacterial infections

AbstractObjectiveThe aim of this article is to compare the efficacy and safety of doripenem for bacterial infections.MethodsWe included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014. The included trials compared efficacy and safety of doripenem for complicated intra-abdominal infections, complicated urinary tract infection, nosocomial pneumonia, and acute biliary tract infection. The meta-analysis was carried on by the statistical software of Review Manager, version 5.2.ResultsCompared with empirical antimicrobial agents on overall treatment efficacy, doripenem was associated with similar clinical and microbiological treatment success rates (for the clinical evaluable population, odds ratio [OR]=1.26, 95% confidence interval [CI] 0.93–1.69, p=0.13; for clinical modified intent-to-treatment population, OR=0.88, 95% CI 0.55–1.41, p=0.60; for microbiology evaluable population, OR=1.16, 95% CI 0.90–1.50, p=0.26; for microbiological modified intent-to-treatment (m-mITT), OR=0.98, 95% CI 0.81–1.20, p=0.87). We compared incidence of adverse events and all-cause mortality to analyze treatment safety. The outcomes suggested that doripenem was similar to comparators in terms of incidence of adverse events and all-cause mortality on modified intent-to-treatment population (for incidence of AEs, OR=1.10, 95% CI 0.90–1.35, p=0.33; for all-cause mortality, OR=1.08, 95% CI 0.77–1.51, p=0.67). In nosocomial pneumonia and ventilator-associated pneumonia treatment, doripenem was not inferior to other antibacterial agents in terms of efficacy and safety.ConclusionFrom this meta-analysis, we can conclude that doripenem is as valuable and well-tolerated than empirical antimicrobial agents for complicated intra-abdominal infections, complicated urinary tract infection, acute biliary tract infection and nosocomial pneumonia treatment

Diethyl 2,2′-[(5-dimethyl­amino-1-naphth­yl)sulfonyl­imino]diacetate

In the title compound, C20H26N2O6S, the N atom of the dimethyl­amino group is displaced by 0.113 (2) Å from the plane of the naphthalene ring system. The two eth­oxy groups adopt zigzag conformations. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds link the mol­ecules, forming a three-dimensional network. Both ethyl groups are disordered over two sites with the ratios of refined occupancies being 0.857 (16):0.143 (16) and 0.517 (14):0.483 (14)

Re-ranking Method Based on Topic Word Pairs

PACLIC 20 / Wuhan, China / 1-3 November, 200

Time-varying β\beta-model for dynamic directed networks

We extend the well-known $\beta$-model for directed graphs to dynamic network setting, where we observe snapshots of adjacency matrices at different time points. We propose a kernel-smoothed likelihood approach for estimating $2n$ time-varying parameters in a network with $n$ nodes, from $N$ snapshots. We establish consistency and asymptotic normality properties of our kernel-smoothed estimators as either $n$ or $N$ diverges. Our results contrast their counterparts in single-network analyses, where $n\to\infty$ is invariantly required in asymptotic studies. We conduct comprehensive simulation studies that confirm our theory's prediction and illustrate the performance of our method from various angles. We apply our method to an email data set and obtain meaningful results

Continuous workload control order release revisited:an assessment by simulation

Order release is a key component of the Workload Control concept. Jobs do not enter the shop floor directly – they are retained in a pre-shop pool and released in time to meet due dates while keeping work-in-process within limits or norms. There are two important groups of release methods: continuous methods, for which the workload falling to a specified level can trigger a release at any moment in time; and, periodic release methods, for which releases take place at fixed intervals. Continuous release methods in general have been shown to outperform periodic release methods. Yet, there is incongruence in the results presented in the literature on the relative performance of the various continuous release methods. We use a job shop simulation model to examine the performance of continuous release methods from the literature and find that the contradictory results are explained by the different rules applied to sequence jobs in the pool – a factor neglected in previous work. Finally, a new breed of continuous release methods has recently emerged, but these have not been compared with prior approaches. Therefore, we also examine these methods and show that they significantly improve overall performance, although this is to the detriment of jobs with large processing times

Circular supply chain management: A definition and structured literature review

Circular economy is increasingly recognized as a better alternative to the dominant linear (take, make, and dispose) economic model. Circular Supply Chain Management (CSCM), which integrates the philosophy of the circular economy into supply chain management, offers a new and compelling perspective to the supply chain sustainability domain. Consequently, there is increasing research interest. However, a review of the extant literature shows that a comprehensive integrated view of CSCM is still absent in the extant literature. This prohibits a clear distinction compared to other supply chain sustainability concepts and hinders further progress of the field. In response, this research first classifies various terminologies related to supply chain sustainability and conceptualizes a unifying definition of CSCM. Using this definition as a base, it then conducts a structured literature review of 261 research articles on the current state of CSCM research. Based on the review results, the researchers call for further studies in the following directions that are important but received little or no attention: design for circularity, procurement and CSCM, biodegradable packaging, circular supply chain collaboration and coordination, drivers and barriers of CSCM, circular consumption, product liabilities and producer's responsibility, and technologies and CSCM

Observation of Distinct Phase Transitions in a Nonlinear Optical Ising Machine

Optical Ising machines promise to solve complex optimization problems with an optical hardware acceleration advantage. Here we study the ground state properties of a nonlinear optical Ising machine realized by spatial light modulator, Fourier optics, and second harmonic generation in a nonlinear crystal. By tuning the ratio of the light intensities at the fundamental and second harmonic frequencies, we experimentally observe two distinct ferromagnetic-to-paramagnetic phase transitions: a second-order phase transition where the magnetization changes to zero continuously and a first-order phase transition where the magnetization drops to zero abruptly as the effective temperature increases. Our experimental results are corroborated by a numerical simulation based on the Monte Carlo Metropolis-Hastings algorithm, and the physical mechanism for the distinct phase transitions can be understood with a mean-field theory. Our results showcase the great flexibility of the nonlinear optical Ising machine, which may find important potential applications in solving combinatorial optimization problems.Comment: 7 pages, 4 figure